Sjögren's Syndrome Knowledge Base


Gene UniProt Primary Name AKA Antigen Details Notes
CEACAM5 P06731 carcinoembryonic antigen-related cell adhesion molecule 5 CD66e
CEA
details upregulated in serum, Tissue: Serum
GOLGA4 Q13439 golgin A4 GCP2
GOLG
golgi autoantigen, golgin subfamily a, 4
golgin 245
golgin-240
p230
AAG details
DDX39B Q13838 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B BAT1
D6S81E
HLA-B associated transcript 1
U2AF65-associated protein 56
UAP56
details
PRRC2A P48634 proline-rich coiled-coil 2A BAT2
D6S51E
G2
HLA-B associated transcript 2
details
HLA-DRB3 P79483 major histocompatibility complex, class II, DR beta 3 HLA-DR3B details
CD5 P06127 CD5 molecule CD5 antigen (p56-62)
LEU1
T1
details
BCKDHB P21953 branched chain keto acid dehydrogenase E1, beta polypeptide maple syrup urine disease AAG details mitochondrial
DLAT P10515 dihydrolipoamide S-acetyltransferase DLTA
E2 component of pyruvate dehydrogenase complex
PDC-E2
details PBC = primary biliary cirrhosis; false positive
OGDH Q02218 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) E1k details
PDHA1 P08559 pyruvate dehydrogenase (lipoamide) alpha 1 PDHA AAG details
MBP P02686 myelin basic protein details
ICOS Q9Y6W8 inducible T-cell co-stimulator AILIM
CD278
activation-inducible lymphocyte immunomediatory molecule
details
UCHL1 P09936 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) PARK5
PGP9.5
Uch-L1
details
CA1 P00915 carbonic anhydrase I Car1 AAG details Jiang 10-15-07
ITGA1 P56199 integrin, alpha 1 CD49a
VLA1
details messenger RNA (mRNA) levels were increased in intercalated duct and acinar cells by DHEA and testosterone
TFRC P02786 transferrin receptor (p90, CD71) CD71
TFR1
details 1 or 2
C2 P06681 complement component 2 details C2 deficiency in autoimmune disease
PRSS1 P07477 protease, serine, 1 (trypsin 1) TRY1 details
MS4A1 P11836 membrane-spanning 4-domains, subfamily A, member 1 B1
Bp35
CD20
MS4A2
details
CR1 P17927 complement component (3b/4b) receptor 1 (Knops blood group) CD35
KN
complement component (3b/4b) receptor 1, including Knops blood group system
details
FN1 P02751 fibronectin 1 CIG
FINC
GFND2
LETS
MSF
cold-insoluble globulin
migration-stimulating factor
details
DES P17661 desmin CMD1I
CSM1
CSM2
intermediate filament protein
AAG details
GAST P01350 gastrin GAS details
GPT P24298 glutamic-pyruvate transaminase (alanine aminotransferase) ALT1
GPT1
details
LCN1 P31025 lipocalin 1 MGC71975
PMFA
TLC
TP
VEGP
Von Ebner gland protein
lipocalin 1 (protein migrating faster than albumin, tear prealbumin)
lipocalin 1 (tear prealbumin)
lipocalin 1-like 2
tear lipocalin
tear prealbumin
AAG details tears
C4B P0C0L5 complement component 4B (Chido blood group) C4B1
C4B3
C4F
CH
CO4
CPAMD3
complement component 4B
details
CALCA P01258 calcitonin-related polypeptide alpha CALC1
calcitonin
calcitonin 1
AAG details
PTH P01270 parathyroid hormone PTH1
parathormone
parathyrin
parathyroid hormone 1
AAG details
TGFB2 P61812 transforming growth factor, beta 2 details
PCNA P12004 proliferating cell nuclear antigen AAG details 12666714
COIL P38432 coilin CLN80
p80-coilin
AAG details
HP P00738 haptoglobin details
ITGAL P20701 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) CD11A
LFA-1
details
MGMT P16455 O-6-methylguanine-DNA methyltransferase details
RPA1 P27694 replication protein A1, 70kDa HSSB
REPA1
RF-A
RP-A
RPA70
replication protein A1 (70kD)
AAG details
RPA2 P15927 replication protein A2, 32kDa replication protein A2 (32kD) AAG details
SLC4A2 P04920 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) AE2
BND3L
EPB3L1
HKB3
NBND3
anion exchanger 2 type a
anion exchanger 2 type b1
anion exchanger 2 type b2
details
HIST1H1E P10412 histone cluster 1, H1e H1 histone family, member 4
H1.4
H1F4
histone 1, H1e
AAG details
ELAVL4 P26378 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) HUD
PNEM
AAG details 8649581
EGF P01133 epidermal growth factor epidermal growth factor (beta-urogastrone) details
HMGN2 P05204 high mobility group nucleosomal binding domain 2 HMG17
high-mobility group (nonhistone chromosomal) protein 17
high-mobility group nucleosomal binding domain 2
AAG details
FCGR2A P12318 Fc fragment of IgG, low affinity IIa, receptor (CD32) CD32
CD32A
CDw32
FCG2
FCGR2
FCGR2A1
Fc fragment of IgG, low affinity IIa, receptor for (CD32)
IGFR2
Immunoglobulin G Fc receptor II
AAG details
ITGA4 P13612 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) CD49D
CD49d
details
AMY2A P04746 amylase, alpha 2A (pancreatic) AMY2
amylase, alpha 2A; pancreatic
details
BPIFA2 Q96DR5 BPI fold containing family A, member 2 C20orf70
PSP
SPLUNC2
bA49G10.1
chromosome 20 open reading frame 70
details NOD mouse
PIGR P01833 polymeric immunoglobulin receptor details
TXN P10599 thioredoxin TRX details
PTPRC P08575 protein tyrosine phosphatase, receptor type, C CD45
GP180
LCA
T200
details Cyclooxygenase-1
FCGR3A P08637 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) CD16
CD16a
FCG3
FCGR3
Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
AAG details 8738962
MME P08473 membrane metallo-endopeptidase CALLA
CD10
NEP
enkephalinase
neprilysin
neutral endopeptidase
details
POU2F1 P14859 POU class 2 homeobox 1 OCT1
OTF1
POU domain class 2, transcription factor 1
details
CD33 P20138 CD33 molecule CD33 antigen (gp67)
FLJ00391
SIGLEC-3
SIGLEC3
p67
sialic acid binding Ig-like lectin 3
details
CD34 P28906 CD34 molecule CD34 antigen details
NUMA1 Q14980 nuclear mitotic apparatus protein 1 AAG details
AR P10275 androgen receptor AIS
DHTR
HUMARA
Kennedy disease
NR3C4
SBMA
SMAX1
dihydrotestosterone receptor
spinal and bulbar muscular atrophy
testicular feminization
details
PLG P00747 plasminogen AAG details
FCER2 P06734 Fc fragment of IgE, low affinity II, receptor for (CD23) CD23
CD23A
CLEC4J
FCE2
Fc fragment of IgE, low affinity II, receptor for (CD23A)
details
LAMB1 P07942 laminin, beta 1 CLM
cutis laxa with marfanoid phenotype
details
CASP1 P29466 caspase 1, apoptosis-related cysteine peptidase ICE
IL1BC
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
caspase-1
interleukin 1, beta, convertase
details
CASP2 P42575 caspase 2, apoptosis-related cysteine peptidase ICH1
NEDD2
PPP1R57
neural precursor cell expressed, developmentally down-regulated 2
protein phosphatase 1, regulatory subunit 57
details
CASP3 P42574 caspase 3, apoptosis-related cysteine peptidase CPP32
CPP32B
Yama
apopain
caspase 3, apoptosis-related cysteine protease
details
CDKN1A P38936 cyclin-dependent kinase inhibitor 1A (p21, Cip1) CAP20
CDKN1
CIP1
P21
SDI1
WAF1
p21CIP1
p21Cip1/Waf1
details
EP300 Q09472 E1A binding protein p300 KAT3B
histone acetyltransferase p300
p300
details remove 8286835
KAT2B Q92831 K(lysine) acetyltransferase 2B GCN5
GCN5L
P/CAF
PCAF
p300/CBP-associated factor
details
PTCRA Q6ISU1 pre T-cell antigen receptor alpha PT-ALPHA
PTA
details
TIMP2 P16035 TIMP metallopeptidase inhibitor 2 CSC-21K
tissue inhibitor of metalloproteinase 2
details
TAP1 Q03518 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) ABCB2
D6S114E
PSF1
RING4
details
TAP2 Q03519 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) ABCB3
D6S217E
PSF2
RING11
details
GOLGA1 Q92805 golgin A1 MGC33154
golgi autoantigen, golgin subfamily a, 1
golgin-97
AAG details overall attenuated and delayed LH and FSH response to LHRH stimulation
GTF2F1 P35269 general transcription factor IIF, polypeptide 1, 74kDa BTF4
RAP74
TF2F1
TFIIF
general transcription factor IIF, polypeptide 1 (74kD subunit)
AAG details
EGFR P00533 epidermal growth factor receptor ERBB
ERBB1
epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
details
CD44 P16070 CD44 molecule (Indian blood group) CD44 antigen (homing function and Indian blood group system)
CD44R
CSPG8
HCELL
IN
MC56
MDU2
MDU3
MIC4
Pgp1
chondroitin sulfate proteoglycan 8
hematopoietic cell E- and L-selectin ligand
details
MYB P10242 v-myb myeloblastosis viral oncogene homolog (avian) c-myb
v-myb avian myeloblastosis viral oncogene homolog
details
CD46 P15529 CD46 molecule, complement regulatory protein CD46 antigen, complement regulatory protein
MCP
MGC26544
MIC10
TLX
TRA2.10
antigen identified by monoclonal antibody TRA-2-10
membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
details
CD55 P08174 CD55 molecule, decay accelerating factor for complement (Cromer blood group) CR
CROM
DAF
TC
decay accelerating factor for complement (CD55, Cromer blood group system)
details
CD59 P13987 CD59 molecule, complement regulatory protein 16.3A5
CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
CD59 antigen, complement regulatory protein
EJ16
EJ30
EL32
G344
MIC11
MIN1
MIN2
MIN3
MSK21
p18-20
details
CLU P10909 clusterin APOJ
CLI
KUB1
SGP-2
SP-40
TRPM-2
apolipoprotein J
clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
complement lysis inhibitor
sulfated glycoprotein 2
testosterone-repressed prostate message 2
details
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 HLA-DR1B details
SSSCA1 O60232 Sjogren syndrome/scleroderma autoantigen 1 Sjogren's syndrome/scleroderma autoantigen 1
p27
AAG details
SELE P16581 selectin E CD62E
ELAM
ELAM1
ESEL
endothelial adhesion molecule 1
details
FCGR1A P12314 Fc fragment of IgG, high affinity Ia, receptor (CD64) CD64
CD64A
Fc fragment of IgG, high affinity Ia, receptor for (CD64)
details
PRH2 P02810 proline-rich protein HaeIII subfamily 2 Pr
acidic salivary proline-rich protein, HaeIII type, 2
parotid proline-rich protein
details
MUC1 P15941 mucin 1, cell surface associated CD227
PEM
PUM
mucin 1, transmembrane
details
IL1RN P18510 interleukin 1 receptor antagonist ICIL-1RA
IL-1RN
IL1F3
IL1RA
IRAP
MGC10430
interleukin-1 receptor antagonist protein
intracellular interleukin-1 receptor antagonist
details
PRF1 P14222 perforin 1 (pore forming protein) HPLH2
P1
PFP
Perforin
perforin 1 (preforming protein)
details
CENPA P49450 centromere protein A CENP-A
CenH3
centromere protein A (17kD)
centromere protein A, 17kDa
centromere-specific histone
histone H3-like centromeric protein A
details
AMY1C P04745 amylase, alpha 1C (salivary) AMY1
amylase, alpha 1C; salivary
AAG details Kalk WW, Vissink A, Spijkervet FK, Bootsma H, Kallenberg CG, Nieuw Amerongen AV.
PRSS2 P07478 protease, serine, 2 (trypsin 2) TRY2 details
SLPI P03973 secretory leukocyte peptidase inhibitor ALK1
ALP
BLPI
HUSI
HUSI-I
WAP4
WFDC4
antileukoproteinase
secretory leukocyte protease inhibitor (antileukoproteinase)
details
FAS P25445 Fas (TNF receptor superfamily, member 6) APO-1
APT1
CD95
FAS1
TNFRSF6
tumor necrosis factor receptor superfamily, member 6
details
ICAM3 P32942 intercellular adhesion molecule 3 CD50
CDW50
ICAM-R
details
RAG1 P15918 recombination activating gene 1 MGC43321
RING finger protein 74
RNF74
V(D)J recombination-activating protein 1
recombination activating protein 1
details VDJ recombinase enzyme complex contains RAG1
PSMA4 P25789 proteasome (prosome, macropain) subunit, alpha type, 4 HC9
HsT17706
AAG details
ACTA1 P68133 actin, alpha 1, skeletal muscle ACTA details
MAPK14 Q16539 mitogen-activated protein kinase 14 CSBP1
CSBP2
CSPB1
Mxi2
PRKM14
PRKM15
p38
p38 MAP kinase
details could not select exact form
MAPK9 P45984 mitogen-activated protein kinase 9 JNK2
Jun kinase
PRKM9
SAPK
p54a
details JNK2 selected from Promega antibody reactivity
EPX P11678 eosinophil peroxidase EPO
EPP
EPX-PEN
details IPA
RNASE3 P12724 ribonuclease, RNase A family, 3 ECP
RNS3
eosinophil cationic protein
details
ESR1 P03372 estrogen receptor 1 ESR
Era
NR3A1
details
PLAUR Q03405 plasminogen activator, urokinase receptor CD87
UPAR
URKR
urokinase plasminogen activator surface receptor
urokinase-type plasminogen activator (uPA) receptor
details
KLK1 P06870 kallikrein 1 Klk6
kallikrein 1, renal/pancreas/salivary
AAG details
MMP2 P08253 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) CLG4
CLG4A
TBE-1
matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase)
matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
details
KRT19 P08727 keratin 19 40-kDa keratin intermediate filament
CK19
K19
K1CS
MGC15366
cytokeratin 19
keratin, type I cytoskeletal 19
keratin, type I, 40-kd
AAG details
TGFA P01135 transforming growth factor, alpha details
GSTM1 P09488 glutathione S-transferase mu 1 GST1
H-B
MU
glutathione S-transferase M1
details
MYC P01106 v-myc myelocytomatosis viral oncogene homolog (avian) bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog
details
A2M P01023 alpha-2-macroglobulin CPAMD5
FWP007
S863-7
details
IGF1 P05019 insulin-like growth factor 1 (somatomedin C) IGF1A details
PRL P01236 prolactin details
PRLR P16471 prolactin receptor details
S100A6 P06703 S100 calcium binding protein A6 2A9
CABP
CACY
PRA
S100 calcium binding protein A6 (calcyclin)
S100 calcium-binding protein A6 (calcyclin)
details
DCN P07585 decorin DSPG2
SLRR1B
decorin proteoglycan
details
FMR1 Q06787 fragile X mental retardation 1 FMRP
FRAXA
MGC87458
POF
POF1
premature ovarian failure 1
details
TCP1 P17987 t-complex 1 CCT1
Ccta
D6S230E
AAG details one of 8 related CCT antigens
HSPD1 P10809 heat shock 60kDa protein 1 (chaperonin) GROEL
HSP60
SPG13
heat shock 60kD protein 1 (chaperonin)
spastic paraplegia 13 (autosomal dominant)
AAG details 18668586
PTGS1 P23219 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) COX1
PGHS-1
PTGHS
details
MMP3 P08254 matrix metallopeptidase 3 (stromelysin 1, progelatinase) STMY
STMY1
matrix metalloproteinase 3 (stromelysin 1, progelatinase)
details
MMP9 P14780 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) CLG4B
matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase)
matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
details
GAD1 Q99259 glutamate decarboxylase 1 (brain, 67kDa) GAD
glutamate decarboxylase 1 (brain, 67kD)
AAG details
CCL18 P55774 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) AMAC-1
CKb7
DC-CK1
DCCK1
MIP-4
PARC
SCYA18
small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
details IPA
CCL19 Q99731 chemokine (C-C motif) ligand 19 CC chemokine ligand 19
CK beta-11
CKb11
EBI1-ligand chemokine
ELC
MIP-3b
SCYA19
beta chemokine exodus-3
exodus-3
macrophage inflammatory protein 3-beta
small inducible cytokine subfamily A (Cys-Cys), member 19
details
GNRH1 P01148 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) GNRH
GRH
LHRH
gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
details
FCGR3B O75015 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) CD16
CD16b
FCG3
FCGR3
Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
AAG details
MBL2 P11226 mannose-binding lectin (protein C) 2, soluble COLEC1
MBL
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
details IPA
ABCA1 O95477 ATP-binding cassette, sub-family A (ABC1), member 1 ABC1
HDLDT1
TGD
Tangier disease
AAG details Tanaka AR, Ikeda Y, Abe-Dohmae S, Arakawa R, Sadanami K, Kidera A, Nakagawa S, Nagase T, Aoki R, Kioka N, Amachi T, Yokoyama S, Ueda K.
CD4 P01730 CD4 molecule CD4 antigen (p55)
T-cell surface glycoprotein CD4
details
DNASE1 P24855 deoxyribonuclease I DNL1 details
SELL P14151 selectin L CD62L
LAM-1
LAM1
LNHR
LSEL
LYAM1
Leu-8
Lyam-1
PLNHR
hLHRc
lymphocyte adhesion molecule 1
details
FTH1 P02794 ferritin, heavy polypeptide 1 FHC
FTH
FTHL6
PIG15
PLIF
apoferritin
placenta immunoregulatory factor
proliferation-inducing protein 15
details
AMBP P02760 alpha-1-microglobulin/bikunin precursor EDC1
HCP
HI30
IATIL
ITI
ITIL
ITILC
UTI
bikunin
complex-forming glycoprotein heterogeneous in charge
growth-inhibiting protein 19
inter-alpha-trypsin inhibitor light chain
protein HC
trypstatin
uristatin
uronic-acid-rich protein
details
TRIM68 Q6AZZ1 tripartite motif containing 68 FLJ10369
RNF137
SS-56
ring finger protein 137
tripartite motif-containing 68
AAG details
SPTBN1 Q01082 spectrin, beta, non-erythrocytic 1 AAG details
BAD Q92934 BCL2-associated agonist of cell death BBC2
BCL2L8
details
CXCL12 P48061 chemokine (C-X-C motif) ligand 12 PBSF
SCYB12
SDF-1a
SDF-1b
SDF1
SDF1A
SDF1B
TLSF-a
TLSF-b
TPAR1
stromal cell-derived factor 1
details
CXCR4 P61073 chemokine (C-X-C motif) receptor 4 CD184
D2S201E
HM89
HSY3RR
LESTR
NPY3R
NPYR
NPYY3R
chemokine (C-X-C motif), receptor 4 (fusin)
fusin
details IP-10 receptor
DPP4 P27487 dipeptidyl-peptidase 4 ADCP2
CD26
DPPIV
adenosine deaminase complexing protein 2
dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
details
TP53 P04637 tumor protein p53 LFS1
Li-Fraumeni syndrome
p53
details
CRISP3 P54108 cysteine-rich secretory protein 3 Aeg2
CRISP-3
CRS3
SGP28
dJ442L6.3
details CD35
HSPA5 P11021 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) BiP
GRP78
heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
AAG details
MUC5AC P98088 mucin 5AC, oligomeric mucus/gel-forming MUC5
mucin 5, subtypes A and C, tracheobronchial/gastric
details
PARP1 P09874 poly (ADP-ribose) polymerase 1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
ADPRT
PARP
PPOL
poly (ADP-ribose) polymerase family, member 1
details
GNAI2 P04899 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 GIP
GNAI2B
GTP-binding regulatory protein Gi alpha-2 chain
details
LAPTM5 Q13571 lysosomal protein transmembrane 5 lysosomal multispanning membrane protein 5 details
UCP2 P55851 uncoupling protein 2 (mitochondrial, proton carrier) SLC25A8 details
VIM P08670 vimentin details
CXCR5 P32302 chemokine (C-X-C motif) receptor 5 BLR1
Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
Burkitt lymphoma receptor 1, GTP-binding protein
CD185
MDR15
details CD185
IL13 P35225 interleukin 13 ALRH
BHR1
Bronchial hyperresponsiveness-1 (bronchial asthma)
IL-13
MGC116786
MGC116788
MGC116789
P600
allergic rhinitis
details GCC haplotype associated with pSS
XIAP P98170 X-linked inhibitor of apoptosis API3
BIRC4
baculoviral IAP repeat-containing 4
hILP
details 11005210
UBC P0CG48 ubiquitin C polyubiquitin-C details Gene: UBC
CTSS P25774 cathepsin S details
IL10 P22301 interleukin 10 CSIF
IL-10
IL10A
T-cell growth inhibitory factor
TGIF
cytokine synthesis inhibitory factor
details promoter also involved 18612930
LGALS9 O00182 lectin, galactoside-binding, soluble, 9 LGALS9A
galectin 9
details
CD80 P33681 CD80 molecule B-lymphocyte activation antigen B7
B7-1
B7.1
CD28LG
CD28LG1
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
CD80 molecule
details
ICA1 Q05084 islet cell autoantigen 1, 69kDa ICAp69
islet cell autoantigen 1 (69kD)
AAG details
CXCL9 Q07325 chemokine (C-X-C motif) ligand 9 CMK
Humig
MIG
SCYB9
crg-10
monokine induced by gamma interferon
details
CCR5 P51681 chemokine (C-C motif) receptor 5 (gene/pseudogene) CC-CKR-5
CD195
CKR-5
CKR5
CMKBR5
IDDM22
chemokine (C-C motif) receptor 5
details
LPL P06858 lipoprotein lipase LIPD details
AQP1 P29972 aquaporin 1 (Colton blood group) CHIP28
CO
Colton blood group
aquaporin 1 (channel-forming integral protein, 28kDa)
aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group)
details
TNFRSF10A O00220 tumor necrosis factor receptor superfamily, member 10a Apo2
CD261
DR4
TRAILR-1
details
TNFRSF10B O14763 tumor necrosis factor receptor superfamily, member 10b CD262
DR5
KILLER
TRAIL-R2
TRICK2A
TRICKB
details
TNFSF10 P50591 tumor necrosis factor (ligand) superfamily, member 10 Apo-2L
CD253
TL2
TRAIL
details
CTLA4 P16410 cytotoxic T-lymphocyte-associated protein 4 CD
CD152
CD28
CELIAC3
GSE
ICOS
celiac disease 3
details
FASLG P48023 Fas ligand (TNF superfamily, member 6) APT1LG1
CD178
FasL
TNFSF6
tumor necrosis factor (ligand) superfamily, member 6
details
ORM2 P19652 orosomucoid 2 AGP-B
AGP-B'
AGP2
alpha-1-acid glycoprotein, type 2
details
PDCD1 Q15116 programmed cell death 1 CD279
PD1
details
TGFB1 P01137 transforming growth factor, beta 1 CED
Camurati-Engelmann disease
DPD1
TGFB
TGFbeta
details
IGF1R P08069 insulin-like growth factor 1 receptor CD221
IGFIR
IGFR
JTK13
MGC18216
details
INSR P06213 insulin receptor CD220 details
SERPINH1 P50454 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) CBP1
CBP2
HSP47
SERPINH2
colligen
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2
AAG details
CD86 P42081 CD86 molecule B-lymphocyte antigen B7-2
B7-2
B7.2
CD28LG2
CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
details
SHBG P04278 sex hormone-binding globulin ABP
MGC126834
MGC138391
TEBG
androgen binding protein
details
ITGB2 P05107 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) CD18
LFA-1
MAC-1
MFI7
integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
details
FOS P01100 FBJ murine osteosarcoma viral oncogene homolog AP-1
c-fos
v-fos FBJ murine osteosarcoma viral oncogene homolog
details
KLK7 P49862 kallikrein-related peptidase 7 PRSS6
SCCE
kallikrein 7 (chymotryptic, stratum corneum)
details
KRT16 P08779 keratin 16 NEPPK
focal non-epidermolytic palmoplantar keratoderma
details
KRT6B P04259 keratin 6B KRTL1
keratin-like 1 (a type II keratin sequence)
details
KRT6C P48668 keratin 6C KRT6E
keratin 6E
details
NOS2 P35228 nitric oxide synthase 2, inducible HEP-NOS
NOS
NOS2A
iNOS
nitric oxide synthase 2A (inducible, hepatocytes)
details
GGT1 P19440 gamma-glutamyltransferase 1 CD224
D22S672
D22S732
GGT
details
SAA2 P02735 serum amyloid A2 details
CTSG P08311 cathepsin G CG AAG details
CELA1 Q9UNI1 chymotrypsin-like elastase family, member 1 ELA1
elastase 1, pancreatic
AAG details
PRTN3 P24158 proteinase 3 ACPA
AGP7
C-ANCA
MBT
P29
PR-3
Wegener granulomatosis autoantigen
myeloblastin
serine proteinase, neutrophil
AAG details
PRKCA P17252 protein kinase C, alpha PKCA details not in NOD
PRKCB P05771 protein kinase C, beta PKCB
PRKCB1
PRKCB2
protein kinase C, beta 1
details not in NOD
ALPL P05186 alkaline phosphatase, liver/bone/kidney HOPS
TNSALP
details LANGR F, HRADSKY M, VORTEL V, PARIZEK J.
BCHE P06276 butyrylcholinesterase CHE1
E1
cholinesterase 1
details BCHE
TOP1 P11387 topoisomerase (DNA) I AAG details
TROVE2 P10155 TROVE domain family, member 2 SSA2
Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro)
AAG details
TG P01266 thyroglobulin AITD3
TGN
AAG details
TPO P07202 thyroid peroxidase TPX AAG details
CCL17 Q92583 chemokine (C-C motif) ligand 17 ABCD-2
SCYA17
TARC
small inducible cytokine subfamily A (Cys-Cys), member 17
details TARC
CCL22 O00626 chemokine (C-C motif) ligand 22 A-152E5.1
ABCD-1
DC/B-CK
MDC
MGC34554
SCYA22
STCP-1
small inducible cytokine subfamily A (Cys-Cys), member 22
details association unclear
TGM2 P21980 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) TGC details
MALT1 Q9UDY8 mucosa associated lymphoid tissue lymphoma translocation gene 1 MLT
paracaspase
details
PSME1 Q06323 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) IFI5111
PA28alpha
AAG details
LTA P01374 lymphotoxin alpha (TNF superfamily, member 1) LT
TNFB
TNFSF1
details
CD72 P21854 CD72 molecule CD72 antigen
CD72b
LYB2
details
FLG P20930 filaggrin details
CD69 Q07108 CD69 molecule CD69 antigen (p60, early T-cell activation antigen)
CLEC2C
details
CHRM1 P11229 cholinergic receptor, muscarinic 1 acetylcholine receptor, muscarinic 1 AAG details
LMNA P02545 lamin A/C CMD1A
HGPS
LGMD1B
LMN1
LMNL1
PRO1
cardiomyopathy, dilated 1A (autosomal dominant)
lamin A/C-like 1
limb girdle muscular dystrophy 1B (autosomal dominant)
progeria 1 (Hutchinson-Gilford type)
AAG details
CD28 P10747 CD28 molecule CD28 antigen (Tp44)
T-cell-specific surface glycoprotein
details
GAL P22466 galanin prepropeptide GALN
GLNN
GMAP
galanin
galanin-message-associated peptide
details
NPY P01303 neuropeptide Y PYY4 details
CENPB P07199 centromere protein B, 80kDa centromere protein B (80kD) AAG details
CENPC1 Q03188 centromere protein C 1 CENP-C
CENPC
MIF2
hcp-4
details
GRAP Q13588 GRB2-related adaptor protein details
CCL4 P13236 chemokine (C-C motif) ligand 4 AT744.1
Act-2
LAG1
MIP-1-beta
SCYA4
small inducible cytokine A4 (homologous to mouse Mip-1b)
details
CCL5 P13501 chemokine (C-C motif) ligand 5 D17S136E
MGC17164
RANTES
SCYA5
SIS-delta
SISd
T-cell specific RANTES protein
T-cell specific protein p288
TCP228
beta-chemokine RANTES
regulated upon activation, normally T-expressed, and presumably secreted
small inducible cytokine A5 (RANTES)
small inducible cytokine subfamily A (Cys-Cys), member 5
details
IL12B P29460 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) CLMF
CLMF2
IL-12B
IL12, subunit p40
NKSF
NKSF2
cytotoxic lymphocyte maturation factor 2, p40
interleukin 12, p40
interleukin-12 beta chain
natural killer cell stimulatory factor, 40 kD subunit
natural killer cell stimulatory factor-2
details
IL15 P40933 interleukin 15 IL-15
MGC9721
details subunit
IL8 P10145 interleukin 8 3-10C
AMCF-I
CXCL8
GCP-1
GCP1
IL-8
K60
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
SCYB8
TSG-1
alveolar macrophage chemotactic factor I
b-ENAP
beta endothelial cell-derived neutrophil activating peptide
chemokine (C-X-C motif) ligand 8
granulocyte chemotactic protein 1
lung giant cell carcinoma-derived chemotactic protein
lymphocyte derived neutrophil activating peptide
monocyte-derived neutrophil chemotactic factor
monocyte-derived neutrophil-activating peptide
neutrophil-activating peptide 1
tumor necrosis factor-induced gene 1
details
TNFRSF1A P19438 tumor necrosis factor receptor superfamily, member 1A CD120a
TNF-R
TNF-R-I
TNF-R55
TNFAR
TNFR1
TNFR60
details
AICDA Q9GZX7 activation-induced cytidine deaminase AID
ARP2
CDA2
HIGM2
details
ATM Q13315 ataxia telangiectasia mutated ATA
ATC
ATD
ATDC
TEL1
TEL1, telomere maintenance 1, homolog (S. cerevisiae)
TELO1
ataxia telangiectasia mutated (includes complementation groups A, C and D)
details
PRKDC P78527 protein kinase, DNA-activated, catalytic polypeptide DNA-PKcs
DNAPK
DNPK1
HYRC
HYRC1
XRCC7
p350
details IPA
AGER Q15109 advanced glycosylation end product-specific receptor RAGE details
CXCL11 O14625 chemokine (C-X-C motif) ligand 11 H174
I-TAC
IP-9
SCYB11
SCYB9B
b-R1
small inducible cytokine subfamily B (Cys-X-Cys), member 11
details
CYP19A1 P11511 cytochrome P450, family 19, subfamily A, polypeptide 1 ARO
ARO1
CPV1
CYAR
CYP19
P-450AROM
aromatase
cytochrome P450, subfamily XIX (aromatization of androgens)
details
APOE P02649 apolipoprotein E AD2
Alzheimer disease 2 (APOE*E4-associated, late onset)
details
VEGFA P15692 vascular endothelial growth factor A VEGF
VEGF-A
VPF
vascular endothelial growth factor
details
CCR4 P51679 chemokine (C-C motif) receptor 4 CC-CKR-4
CD194
CKR4
CMKBR4
ChemR13
k5-5
details
CD68 P34810 CD68 molecule CD68 antigen
CD68 antigen
DKFZp686M18236
GP110
LAMP4
SCARD1
macrophage antigen CD68
macrosialin
scavenger receptor class D, member 1
details IPA
NOS1 P29475 nitric oxide synthase 1 (neuronal) NOS
nNOS
details
NOS3 P29474 nitric oxide synthase 3 (endothelial cell) ECNOS
eNOS
endothelial nitric oxide synthase
details IPA
E2F1 Q01094 E2F transcription factor 1 RBBP3
RBP3
details Affects saliva secretion in NOD/SCID mice, independent of T cells doi: 10.3181/0905-RM-173
AIRE O43918 autoimmune regulator APECED
APS1
PGA1
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
details
CAST P20810 calpastatin AAG details
KLK13 Q9UKR3 kallikrein-related peptidase 13 KLK-L4
kallikrein 13
AAG details
FGF2 P09038 fibroblast growth factor 2 (basic) FGFB details
BAX Q07812 BCL2-associated X protein BCL2L4 details
BCL6 P41182 B-cell CLL/lymphoma 6 BCL5
BCL6A
LAZ3
ZBTB27
ZNF51
zinc finger protein 51
details
CD38 P28907 CD38 molecule ADP-ribosyl cyclase 1
CD38 antigen (p45)
NAD(+) nucleosidase
details
CA4 P22748 carbonic anhydrase IV CAIV
Car4
RP17
retinitis pigmentosa 17 (autosomal dominant)
AAG details
FADD Q13158 Fas (TNFRSF6)-associated via death domain Fas-associating death domain-containing protein
Fas-associating protein with death domain
GIG3
MORT1
growth-inhibiting gene 3 protein
mediator of receptor-induced toxicity
details
CENPH Q9H3R5 centromere protein H NNF1
NNF1, MIND kinetochore complex component, homolog (S. cerevisiae)
PMF1
details
CFLAR O15519 CASP8 and FADD-like apoptosis regulator CASH
CASP8AP1
CLARP
Casper
FLAME
FLIP
I-FLICE
MRIT
c-FLIP
details
CRP P02741 C-reactive protein, pentraxin-related PTX1
pentraxin 1
details low in pSS
BAK1 Q16611 BCL2-antagonist/killer 1 BAK
BCL2L7
CDN1
details D6S439
P2RY2 P41231 purinergic receptor P2Y, G-protein coupled, 2 P2U details
BCL2 P10415 B-cell CLL/lymphoma 2 Bcl-2
PPP1R50
protein phosphatase 1, regulatory subunit 50
details BHRF1 homologue; translocation in MALT
CA2 P00918 carbonic anhydrase II CA-II
CAII
Car2
AAG details
CD3D P04234 CD3d molecule, delta (CD3-TCR complex) CD3d antigen, delta polypeptide (TiT3 complex)
T3D
details
CXCL13 O43927 chemokine (C-X-C motif) ligand 13 ANGIE
ANGIE2
B-cell chemoattractant
BCA-1
BLC
BLR1L
SCYB13
small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
details SDF-1
CCL21 O00585 chemokine (C-C motif) ligand 21 6Ckine
CKb9
ECL
Efficient Chemoattractant for Lymphocytes
SCYA21
SLC
TCA4
beta chemokine exodus-2
exodus-2
secondary lymphoid tissue chemokine
small inducible cytokine subfamily A (Cys-Cys), member 21
details
VIP P01282 vasoactive intestinal peptide details
TNFSF13 O75888 tumor necrosis factor (ligand) superfamily, member 13 APRIL
CD256
details
CD27 P26842 CD27 molecule S152
TNFRSF7
Tp55
tumor necrosis factor receptor superfamily, member 7
details
RGS13 O14921 regulator of G-protein signaling 13 regulator of G-protein signalling 13 details
SERPINA1 P01009 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 A1A
A1AT
AAT
PI
PI1
alpha-1-antitrypsin
alpha1AT
protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
details
KLHL12 Q53G59 kelch-like 12 (Drosophila) C3IP1 AAG details
KLHL7 Q8IXQ5 kelch-like 7 (Drosophila) KLHL6
RP42
SBBI26
kelch (Drosophila)-like 6
retinitis pigmentosa 42
details
CCL11 P51671 chemokine (C-C motif) ligand 11 MGC22554
SCYA11
eotaxin
eotaxin-1
small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
details 16126006
CCL2 P13500 chemokine (C-C motif) ligand 2 GDCF-2
HC11
MCAF
MCP-1
MCP1
MGC9434
SCYA2
SMC-CF
monocyte chemoattractant protein-1
monocyte chemotactic and activating factor
monocyte chemotactic protein 1, homologous to mouse Sig-je
monocyte secretory protein JE
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
small inducible cytokine subfamily A (Cys-Cys), member 2
details Immunohistochemistry showed in situ expression of MCP-1 and CCR2 in the ductal structure and infiltrating mononuclear cells (MNCs) of patients with pSS. Primary salivary epithelial cells in vitro from pSS produced MCP-1, which was significantly stimulated by IFN-gamma, as identified by both ELISA and RT-PCR. In contrast to MCP-1, CCR2 expression of primary salivary epithelial cells in vitro was not so changed by IFN-gamma.
CCL3 P10147 chemokine (C-C motif) ligand 3 G0S19-1
LD78ALPHA
MIP-1-alpha
SCYA3
small inducible cytokine A3 (homologous to mouse Mip-1a)
details 16126006
IL4 P05112 interleukin 4 B cell growth factor 1
BCGF-1
BCGF1
BSF1
B_cell stimulatory factor 1
IL-4
MGC79402
lymphocyte stimulatory factor 1
details
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 CLGI
EPO
TIMP
tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
details
IFNG P01579 interferon, gamma details 11032395
IVL P07476 involucrin details
PTPN22 Q9Y2R2 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Lyp
Lyp1
Lyp2
PTPN8
protein tyrosine phosphatase, non-receptor type 8
details 1858 T allele
B2M P61769 beta-2-microglobulin details
GZMB P10144 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) CCPI
CGL-1
CGL1
CSP-B
CSPB
CTLA1
CTSGL1
HLP
SECT
T-cell serine protease 1-3E
cathepsin G-like 1
cytotoxic serine protease B
fragmentin 2
details
IDO1 P14902 indoleamine 2,3-dioxygenase 1 IDO
INDO
indoleamine-pyrrole 2,3 dioxygenase
details
ABCA7 Q8IZY2 ATP-binding cassette, sub-family A (ABC1), member 7 ABCX AAG details Toda Y, Aoki R, Ikeda Y, Azuma Y, Kioka N, Matsuo M, Sakamoto M, Mori S, Fukumoto M, Ueda K.
CAPN1 P07384 calpain 1, (mu/I) large subunit CANP
CANPL1
muCANP
muCL
details alpha-fodrin proteolysis
C3 P01024 complement component 3 CPAMD1 details
CTSB P07858 cathepsin B details CD152
CTSC P53634 cathepsin C DPP1
PALS
PLS
dipeptidyl peptidase 1
details
DPP7 Q9UHL4 dipeptidyl-peptidase 7 DPPII
dipeptidylpeptidase 7
details
GLB1 P16278 galactosidase, beta 1 EBP
ELNR1
elastin receptor 1 (67kD)
elastin receptor 1, 67kDa
details
GUSB P08236 glucuronidase, beta details
HEXA P06865 hexosaminidase A (alpha polypeptide) GM2 gangliosidosis
Tay Sachs disease
details
HEXB P07686 hexosaminidase B (beta polypeptide) details
MAN2B1 O00754 mannosidase, alpha, class 2B, member 1 LAMAN
MANB
details
MGAM O43451 maltase-glucoamylase (alpha-glucosidase) MGA details
TPP1 O14773 tripeptidyl peptidase I CLN2
TPP I
ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)
details
CD274 Q9NZQ7 CD274 molecule B7 homolog 1
B7-H
B7-H1
B7H1
CD274 antigen
PD-L1
PDCD1LG1
PDL1
programmed cell death 1 ligand 1
details
MAPK8 P45983 mitogen-activated protein kinase 8 JNK
JNK1
JUN N-terminal kinase
PRKM8
SAPK1
details IPA
CD19 P15391 CD19 molecule CD19 antigen details
PSMB9 P28065 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) LMP2
PSMB6i
RING12
beta1i
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)
details dysregulation in lymphocytes - circulating and infiltrating
ALCAM Q13740 activated leukocyte cell adhesion molecule CD166
MEMD
activated leucocyte cell adhesion molecule
details
CD6 P30203 CD6 molecule CD6 antigen
Tp120
details
CXCR3 P49682 chemokine (C-X-C motif) receptor 3 CD183
CKR-L2
CMKAR3
G protein-coupled receptor 9
GPR9
IP10-R
MigR
details
CA6 P23280 carbonic anhydrase VI details saliva marker
CST3 P01034 cystatin C cystatin C (amyloid angiopathy and cerebral hemorrhage) details
IGKC P01834 immunoglobulin kappa constant HCAK1 details
LTF P02788 lactotransferrin HLF2 details
LYZ P61626 lysozyme lysozyme (renal amyloidosis)
renal amyloidosis
details
SPRR2A P35326 small proline-rich protein 2A details
CHRM3 P20309 cholinergic receptor, muscarinic 3 acetylcholine receptor, muscarinic 3 AAG details IPA
CXCL10 P02778 chemokine (C-X-C motif) ligand 10 C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
small inducible cytokine subfamily B (Cys-X-Cys), member 10
details
CD40 P25942 CD40 molecule, TNF receptor superfamily member 5 Bp50
TNFRSF5
p50
tumor necrosis factor receptor superfamily, member 5
details
CD40LG P29965 CD40 ligand CD154
CD40 antigen ligand
CD40L
HIGM1
IMD3
T-B cell-activating molecule
TNF-related activation protein
TNFSF5
TRAP
gp39
hCD40L
hyper-IgM syndrome
tumor necrosis factor (ligand) superfamily member 5
tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
details
PPBP P02775 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) Beta-TG
CTAP3
CTAPIII
CXCL7
LA-PF4
LDGF
MDGF
NAP-2
NAP-2-L1
PBP
SCYB7
TGB
TGB1
THBGB1
b-TG1
beta-thromboglobulin
connective tissue-activating peptide III
neutrophil-activating peptide-2
platelet basic protein
details
CD2 P06729 CD2 molecule CD2 antigen (p50), sheep red blood cell receptor
SRBC
details
KLRK1 P26718 killer cell lectin-like receptor subfamily K, member 1 CD314
D12S2489E
DNA segment on chromosome 12 (unique) 2489 expressed sequence
KLR
NKG2-D
NKG2D
details
NCR1 O76036 natural cytotoxicity triggering receptor 1 CD335
LY94
NK-p46
NKP46
lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)
details
SNRNP70 P08621 small nuclear ribonucleoprotein 70kDa (U1) RNPU1Z
RPU1
SNRP70
Snp1
U1-70K
small nuclear ribonucleoprotein 70kDa (RNP antigen)
AAG details
SNRPA P09012 small nuclear ribonucleoprotein polypeptide A Mud1
U1-A
U1A
AAG details
SNRPA1 P09661 small nuclear ribonucleoprotein polypeptide A' Lea1 AAG details
SNRPB2 P08579 small nuclear ribonucleoprotein polypeptide B Msl1
small nuclear ribonucleoprotein polypeptide B''
small nuclear ribonucleoprotein polypeptide B2
AAG details
SNRPD1 P62314 small nuclear ribonucleoprotein D1 polypeptide 16kDa HsT2456
SNRPD
Sm-D1
small nuclear ribonucleoprotein D1 polypeptide (16kD)
AAG details
SNRPD2 P62316 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa SNRPD1
Sm-D2
small nuclear ribonucleoprotein D2 polypeptide (16.5kD)
snRNP core protein D2
AAG details
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing ACDC
ACRP30
AdipoQ
GBP28
adipocyte, C1Q and collagen domain containing
adiponectin
adipose most abundant gene transcript 1
apM1
details
CSF2 P04141 colony stimulating factor 2 (granulocyte-macrophage) GM-CSF
GMCSF
granulocyte-macrophage colony stimulating factor
molgramostin
sargramostim
details
IL5 P05113 interleukin 5 (colony-stimulating factor, eosinophil) B cell differentiation factor I
EDF
IL-5
T-cell replacing factor
TRF
eosinophil differentiation factor
interleukin-5
details
HBB P68871 hemoglobin, beta CD113t-C
HBD
beta-globin
details
HGF P14210 hepatocyte growth factor (hepapoietin A; scatter factor) DFNB39
F-TCF
HGFB
HPTA
SF
deafness, autosomal recessive 39
fibroblast-derived tumor cytotoxic factor
hepatopoietin A
lung fibroblast-derived mitogen
scatter factor
details or HEXA
CD22 P20273 CD22 molecule CD22 antigen
SIGLEC-2
SIGLEC2
sialic acid binding Ig-like lectin 2
details
LTB Q06643 lymphotoxin beta (TNF superfamily, member 3) TNFC
TNFSF3
p33
details
CD14 P08571 CD14 molecule CD14 antigen details
JUN P05412 jun proto-oncogene AP-1
c-Jun
jun oncogene
v-jun avian sarcoma virus 17 oncogene homolog
v-jun sarcoma virus 17 oncogene homolog (avian)
details
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 JNKK1
MEK4
MKK4
PRKMK4
SERK1
details
APOH P02749 apolipoprotein H (beta-2-glycoprotein I) B2G1
BG
beta-2-glycoprotein I
details 14530197
CD70 P32970 CD70 molecule CD27L
CD27LG
TNFSF7
tumor necrosis factor (ligand) superfamily, member 7
details
ELK1 P19419 ELK1, member of ETS oncogene family details
IRF3 Q14653 interferon regulatory factor 3 details
TNFRSF13B O14836 tumor necrosis factor receptor superfamily, member 13B CD267
TACI
details NOD
TNFRSF19 Q9NS68 tumor necrosis factor receptor superfamily, member 19 TAJ
TAJ-alpha
TRADE
TROY
toxicity and JNK inducer
details NOD
TRAF1 Q13077 TNF receptor-associated factor 1 EBI6 details
TRAF3 Q13114 TNF receptor-associated factor 3 CAP-1
CD40bp
CRAF1
LAP1
details
TRAF6 Q9Y4K3 TNF receptor-associated factor 6, E3 ubiquitin protein ligase RNF85
TNF receptor-associated factor 6
details
IRF1 P10914 interferon regulatory factor 1 MAR
interferon regulatory factor-1
details
NFKBIA P25963 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha IKBA
IkappaBalpha
MAD-3
NFKBI
details
STAT1 P42224 signal transducer and activator of transcription 1, 91kDa ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kD
transcription factor ISGF-3 components p91/p84
details 17513576
AQP5 P55064 aquaporin 5 details
TNF P01375 tumor necrosis factor DIF
TNF superfamily, member 2
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor (TNF superfamily, member 2)
details IPA
ACTB P60709 actin, beta AAG details
POMC P01189 proopiomelanocortin ACTH
CLIP
LPH
MSH
NPP
POC
adrenocorticotropic hormone
adrenocorticotropin
alpha-melanocyte stimulating hormone
beta-endorphin
beta-lipotropin
beta-melanocyte stimulating hormone
details IPA
IL2 P60568 interleukin 2 IL-2
T cell growth factor
TCGF
details
IL2RA P01589 interleukin 2 receptor, alpha CD25
IL2R
details CD-25
KRT7 P08729 keratin 7 CK7
K2C7
K7
SCL
cytokeratin 7
keratin, 55K type II cytoskeletal
keratin, type II cytoskeletal 7
sarcolectin
details
PRKD1 Q15139 protein kinase D1 PKC-mu
PKCM
PKD
PRKCM
protein kinase C, mu
details
ICAM1 P05362 intercellular adhesion molecule 1 BB2
CD54
human rhinovirus receptor
details 15303579
NFKB1 P19838 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 KBF1
NF-kB1
NF-kappaB
NFKB-p50
NFkappaB
p105
p50
details
IL21 Q9HBE4 interleukin 21 IL-21
Za11
details
TLR1 Q15399 toll-like receptor 1 CD281
KIAA0012
rsc786
details
TLR2 O60603 toll-like receptor 2 CD282
TIL4
details
TLR3 O15455 toll-like receptor 3 CD283 details
TLR4 O00206 toll-like receptor 4 CD284
TLR-4
hToll
details
TNFRSF13C Q96RJ3 tumor necrosis factor receptor superfamily, member 13C BAFFR
CD268
details
TNFRSF17 Q02223 tumor necrosis factor receptor superfamily, member 17 BCM
BCMA
CD269
details
CST5 P28325 cystatin D details 16522680
MIF P14174 macrophage migration inhibitory factor (glycosylation-inhibiting factor) GIF
GLIF
details
TMSB10 P63313 thymosin beta 10 TB10 details
TRBC1 P01850 T cell receptor beta constant 1 BV05S1J2.2
TCRBC1
details
XDH P47989 xanthine dehydrogenase XO
XOR
xanthene dehydrogenase
details
IRF8 Q02556 interferon regulatory factor 8 ICSBP
ICSBP1
IRF-8
interferon consensus sequence binding protein 1
details
STAT6 P42226 signal transducer and activator of transcription 6, interleukin-4 induced D12S1644
IL-4-STAT
details
DEFA1B P59665 defensin, alpha 1B details
DEFB4B O15263 defensin, beta 4B DEFB4P
defensin, beta 4, pseudogene
details
VCAM1 P19320 vascular cell adhesion molecule 1 CD106 details
RELA Q04206 v-rel reticuloendotheliosis viral oncogene homolog A (avian) NFKB3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
p65
details
IL1B P01584 interleukin 1, beta IL-1B
IL1-BETA
IL1F2
details
IFI16 Q16666 interferon, gamma-inducible protein 16 IFNGIP1
PYHIN2
AAG details
MUC5B Q9HC84 mucin 5B, oligomeric mucus/gel-forming MG1
MUC5
mucin 5, subtype B, tracheobronchial
details reduced sulfation
IL12A P29459 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) CLMF
IL-12, subunit p35
IL-12A
IL35 subunit
NF cell stimulatory factor chain 1
NFSK
NKSF1
cytotoxic lymphocyte maturation factor 1, p35
interleukin 12, p35
interleukin-12 alpha chain
natural killer cell stimulatory factor 1, 35 kD subunit
p35
details
IL18 Q14116 interleukin 18 (interferon-gamma-inducing factor) IGIF
IL-18
IL-1g
IL1F4
details
IFNA13 P01562 interferon, alpha 13 details IPA
IRF5 Q13568 interferon regulatory factor 5 details
MUC19 Q7Z5P9 mucin 19, oligomeric FLJ35746 details
STAT3 P40763 signal transducer and activator of transcription 3 (acute-phase response factor) APRF details 17513576
IL6 P05231 interleukin 6 (interferon, beta 2) BSF2
HGF
HSF
IFNB2
IL-6
details IPA
NFKBIL1 Q9UBC1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 IKBL
NFKBIL
details 9314950 I kappa B-alpha, a specific inhibitor of NF-kappa B, was down-regulated by treatment with cytokines in NS-SV-AC
ID3 Q02535 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein HEIR-1
bHLHb25
details
SSB P05455 Sjogren syndrome antigen B (autoantigen La) LARP3
La
La ribonucleoprotein domain family, member 3
AAG details Kuwana M, Okano T, Ogawa Y, Kaburaki J, Kawakami Y.
PSMB10 P40306 proteasome (prosome, macropain) subunit, beta type, 10 LMP10
MECL1
MGC1665
beta2i
details
PSMB8 P28062 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) D6S216E
LMP7
PSMB5i
RING10
beta5i
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)
details
SPTAN1 Q13813 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) AAG details 12823984
MPO P05164 myeloperoxidase details
ITGA6 P23229 integrin, alpha 6 CD49f details
ITGB4 P16144 integrin, beta 4 CD104 details
BGN P21810 biglycan DSPG1
SLRR1A
biglycan proteoglycan
details degraded in NOD mice
ADCK1 Q86TW2 aarF domain containing kinase 1 FLJ39600 details
ADH1B P00325 alcohol dehydrogenase 1B (class I), beta polypeptide ADH2 details
ANXA2 P07355 annexin A2 ANX2
ANX2L4
CAL1H
LIP2
LPC2D
annexin II
details
APOA1 P02647 apolipoprotein A-I details
BLVRB P30043 biliverdin reductase B (flavin reductase (NADPH)) FLR
Flavin reductase
SDR43U1
short chain dehydrogenase/reductase family 43U, member 1
details FLR
CAT P04040 catalase details
CMPK1 P30085 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic CMPK
Cytidine monophosphate kinase
UMP-CMP kinase
UMP-CMPK
cytidylate kinase
details
DCD P81605 dermcidin AIDD
DCD-1
DSEP
HCAP
PIF
diffusible survival/evasion peptide
preproteolysin
proteolysis inducing factor
survival promoting peptide
details
DSC1 Q08554 desmocollin 1 CDHF1 details
DSG1 Q02413 desmoglein 1 CDHF4
DSG
details
F7 P08709 coagulation factor VII (serum prothrombin conversion accelerator) FVII coagulation protein
eptacog alfa
factor VII
details IPA
GAPDH P04406 glyceraldehyde-3-phosphate dehydrogenase GAPD details
GLUD1 P00367 glutamate dehydrogenase 1 GDH
GLUD
details
GLUD2 P49448 glutamate dehydrogenase 2 GLUDP1
glutamate dehydrogenase pseudogene 1
details
HBD P02042 hemoglobin, delta details
IGHG1 P01857 immunoglobulin heavy constant gamma 1 (G1m marker) details
IGHG2 P01859 immunoglobulin heavy constant gamma 2 (G2m marker) details
IGHM P01871 immunoglobulin heavy constant mu details
FOXP3 Q9BZS1 forkhead box P3 AIID
DIETER
IPEX
JM2
PIDX
SCURFIN
XPID
immune dysregulation, polyendocrinopathy, enteropathy, X-linked
details The numbers of Foxp3+ Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome.
EZR P15311 ezrin VIL2
cytovillin 2
villin 2 (ezrin)
details
CHRM2 P08172 cholinergic receptor, muscarinic 2 acetylcholine receptor, muscarinic 2 details Ingenuity
CHRM4 P08173 cholinergic receptor, muscarinic 4 acetylcholine receptor, muscarinic 4 details Ingenuity
HMGB1 P09429 high mobility group box 1 Amphoterin
DKFZp686A04236
HMG1
HMG3
SBP-1
Sulfoglucuronyl carbohydrate binding protein
high mobility group box 1
high mobility group protein 1
high-mobility group (nonhistone chromosomal) protein 1
high-mobility group box 1
details Ingenuity
PPP3CA Q08209 protein phosphatase 3, catalytic subunit, alpha isozyme CALN
CALNA
CNA1
PPP2B
calcineurin A alpha
protein phosphatase 2B, catalytic subunit, alpha isoform
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
details Inhibited by cyclosporin A. Clinical trial NCT00001731
CHRM5 P08912 cholinergic receptor, muscarinic 5 acetylcholine receptor, muscarinic 5 details Ingenuity
PPP3CB P16298 protein phosphatase 3, catalytic subunit, beta isozyme CALNA2
CALNB
CNA2
PP2Bbeta
calcineurin A beta
protein phosphatase 2B, catalytic subunit, beta isoform
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
details Ingenuity
PPP3R2 Q96LZ3 protein phosphatase 3, regulatory subunit B, beta PPP3RL
calcineurin B, type II (19kDa)
protein phosphatase 2B regulatory subunit 2
protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), beta isoform (calcineurin B, type II)
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II)
protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform
protein phosphatase 3, regulatory subunit B (calcineurin B)-like
details Inhibited by cyclosporin A, not clear if this is the correct calcineurin
MECP2 P51608 methyl CpG binding protein 2 (Rett syndrome) MRX16
MRX79
RTT
mental retardation, X-linked 16
mental retardation, X-linked 79
details Genetic association
ITGA2 P17301 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) CD49B
CD49b
details messenger RNA (mRNA) levels were increased in intercalated duct and acinar cells by DHEA and testosterone, Tissue: Human LSG
STAT4 Q14765 signal transducer and activator of transcription 4 details These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene
GOLGB1 Q14789 golgin B1 GCP
GCP372
GOLIM1
giantin
golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1
golgi integral membrane protein 1
golgin B1, golgi integral membrane protein
macrogolgin
AAG details
IL7 P13232 interleukin 7 IL-7 details Hs T-cells
TXLNA P40222 taxilin alpha DKFZp451J0118 details IL-14a, interleukin-14 alpha
IL22 Q9GZX6 interleukin 22 IL-10-related T-cell-derived inducible factor
IL-21
IL-22
IL-D110
IL-TIF
ILTIF
MGC79382
MGC79384
TIFIL-23
TIFa
zcyto18
details
IL23A Q9NPF7 interleukin 23, alpha subunit p19 IL-23
IL-23A
IL23P19
P19
SGRF
interleukin-six, G-CSF related factor
details
IL17A Q16552 interleukin 17A CTLA8
IL-17
IL-17A
IL17
cytotoxic T-lymphocyte-associated protein 8
interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
details
IL7R P16871 interleukin 7 receptor CD127 details
PON1 P27169 paraoxonase 1 ESA
PON
esterase A
details decreased in SS patients

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